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Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver-toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. 🔍 #MedEd #
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Clinical toxicity of Acetaminophen
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Q. The LD 50 of acetaminophen is increased in mice with deletions of genes for: 1 . Glutathione synthetase . 2 . CYP 1 A2 and CYP 2 E 1 . 3 . Glucuronyl transferase. 4 . N -acetyl transferase. 5 . Ah receptor
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NAPQI (N-Acetyl-4-benzoquinone Imine) | Acetaminophen Metabolite
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SUPER EASY MEMORY Too much Tylenol → More NAPQI → Less glutathione → Liver dies NAC → More glutathione → Liver saved
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Haggling with HAGMA: A Common Medication with an Uncommon Differential
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What happens when you take paracetamol? 💊 Your liver gets to work breaking it down into harmless bits. But here's the twist... Those bits need a taxi (yep, a molecule called glutathione)
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