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GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. ❓How does ethanol interfere with acetaminophen metabolism? Image: https://t.co/6EY9dIwLXY
28.32
Metabolic pathway for NAPQI formation and detoxification by conjugation...
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NAPQI
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Simplified scheme of APAP metabolism, leading to the formation of NAPQI...
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NAPQI - an overview
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Acetaminophen metabolism. Acetaminophen is metabolized primarily by
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Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine
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