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glp-1 gip news Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy: Cell Reports Medicine

Marsoni M251S
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4.3 ★★★★★
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Michael S
San Leandro, US
★★★★★ 5
Slip ons worth slipping on…
Size: 9.5, Color: Black, Size: 9.5, Color: Black
Very stylish and comfortable. I love how light they are because I’m on my feet all day. The black leather is very deep and very rich. The elevated sole gives me a tad more height, too…which I like. And yes, they’re slip ons. Don’t let the laces fool you. For under $40, these shoes are a strong value to consider…
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 19, 2026
B
Verified Purchase
Boss Babe
Dallas, US
★★★★★ 5
I feel I’m walking on clouds
Size: 10, Color: Brown
I’m on my feet 6–8 hours a day working at the dealership, constantly walking the lot and helping customers—and I’ve gone through a lot of shoes trying to find something that actually holds up. These Bruno Marc MaxFlex Dress Sneakers honestly surprised me. They look sharp and professional enough for work, but feel more like a comfortable athletic shoe than a stiff dress shoe. From day one, there was no break-in period, no soreness, just all-day comfort. I feel I’m walking on clouds! If you’re in a job where you’re standing or moving around a lot but still need to look polished, these are hands down the most comfortable work shoes I’ve owned.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026
B
Verified Purchase
Bryan Combs
San Leandro, US
★★★★★ 5
Dress shoes
Size: 9, Color: Light Brown/Coffee
Very comfortable and well made shoes.
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Reviewed in the United States on May 24, 2026
E
Verified Purchase
erick
Lexington, US
★★★★★ 3
Runs big
Size: 10, Color: Black
Too big , looks okay. Try 1 size down
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Reviewed in the United States on May 13, 2026
M
Verified Purchase
Marco Cervantes
West Palm Beach, US
★★★★★ 5
Great shoes
Size: 10 Wide, Color: Brown, Size: 10 Wide, Color: Brown
This shoe is incredibly comfortable and durable. I work in custodial work as management. However, sometimes I have to help my team when we are low manned. Just recently I had to help my team auto scrub a restroom. My shoes felt lightweight and were completely easy to clean. I was worried I would be slipping on sudsy water. To my surprise, these shoes gripped on to the floor nicely. I love the versatility of having a working shoe with the great style Bruno Marc provides. The shoe is breathable and true to size. I ordered the black pair as well and have had them for about 3 months. Highly recommend these amazing shoes.
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Reviewed in the United States on May 28, 2026

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