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first large study of glp-1 receptor agonists during pregnancy GLP-1 receptor agonist exposure with discontinuation before or during early #pregnancy was associated with greater gestational weight gain and increased risk of preterm delivery, gestational #diabetes, and hypertensive disorders in a cohort

Marsoni M251S
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OZEMPIC: Risks, Benefits, and Natural Alternatives to GLP 1 Weight Loss Drugs Nature Reviews Gastroenterology & Hepatology: GLP 1 receptor agonists are effective pharmacotherapies for the treatment of obesity and related disorders. In metabolic dysfunction associated steatohepatitis with moderate to advanced fibrosis Frontiers GLP1 receptor agonists for the treatment of obesity: Role as a promising approach glp 1_analogs [TUSOM Pharmwiki] Possible mechanisms of action of glucagon like peptide 1 receptor agonists on blood pressure beyond body weight Hypertension Research What is GLP 1 and Its Receptor Agonists? BOC Sciences
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4.0 ★★★★★
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Aleah Pacheco
Massapequa, US
★★★★★ 5
MUST BUY
This was a nice addition to my Prequel collection! I just loved this product and so did my skin. This is a very light weight product that hydrates and plumps the skin. I apply it after my VitC serum and it works great under my makeup. I will be repurchasing. Such a good product at a good price!
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Reviewed in the United States on April 14, 2026
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Rosemarie
Bozeman, US
★★★★★ 5
Makes my skin feel firmer
I bought this and the Prequel SPF, my first time using this product line. Definitely impressed and in my opinion, a great price for what seems like a quality product. The serum has a lightweight texture,, absorbs quickly, and my skin looks and feels well hydrated right away. More so than when I use a regular hyaluronic acid. There is no pilling or heavy feel so easy to use with other products. I can't say whether it improves skin texture over time or what the benefits are with continued use. I've been using it consistently with the SPF for the last two weeks, so it only been a short while. But when I put it on, my skin noticeably looks more springy and feels better throughout the day. I have mature, dry skin so I do use a moisturizer over this before sun protection. I imagine that if you have oily or normal skin you might be able to use this in place of moisturizer during the day.
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Reviewed in the United States on October 27, 2025
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Verified Purchase
L.M.
Waukegan, US
★★★★★ 5
Plump, Soft Skin with a Smooth Finish
I’ve really been enjoying the Prequel Skin Multi‑Quench Plumping Hydration Serum. It gives my skin a soft, hydrated feel without any heaviness, and it absorbs quickly so it never interferes with the rest of my routine. One of the best parts is how smoothly my makeup applies afterward—everything blends better and looks more even. Overall, it’s a lightweight, effective serum that adds the perfect boost of hydration.
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Reviewed in the United States on December 23, 2025
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Verified Purchase
Amos Cookie
Carnegie, US
★★★★★ 5
New favorite moisture serum
I am blown away by this formula - it goes on silky and absorbs into the skin, giving it a plump, hydrated glow without ANY stickiness or annoying shine. Two pumps after cleansing and toner is just right but you can also go in heavier and use in place of a moisturizer. This truly gives me lasting moisture, which is amazing for a light to mid-weight serum. Wears great with other complexion products and under makeup. The glass bottle is luxe and the pump isn't the least bit messy. Glycerin is all the rage in terms of "hot" ingredients right now - and I have to say after using this, I'm a believer. I've pretty much replaced a classic daily moisturizer with pairing this serum before Strata Lipid Gold (another holy grail) - which works great under my moisturizing Japanese sunscreen (Canmake Mermaid Skin). These steps provide a flawless, juicy base under makeup for my maturing (43-year old) skin. Can't wait to try more products in this line.
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Reviewed in the United States on September 29, 2024
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Nicolle Castro
Houston, US
★★★★★ 4
Good
Moisturizing and gel like. It pills when used with the Prequel mineral SPF.
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Reviewed in the United States on March 31, 2026

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