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CONS: ⚠️ Gastrointestinal side effects: Nausea, vomiting, diarrhea, and constipation affect approximately 50-60% of patients, especially during initial treatment. ⚠️ Muscle loss: Up to 39% of weight lost may come from lean
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Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial
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Not every patient responds the same to GLP-1 therapy. In the clinical trials, a subset of patients did not achieve ≥5% weight loss—often considered an “inadequate response” in clinical practice. This highlights
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Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial
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Semaglutide 2.4-mg Injection as a Novel Approach for Chronic Weight Management
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