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Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility
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A. Amino acid sequence comparison for exenatide (synthetic exendin-4)
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Exendin-4 induced retching-like behavior mediated by postsynaptic effect via AMPA receptors in the area postrema of mice | American Journal of Physiology-Endocrinology and Metabolism
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Exendin-4
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Ozempic® (semaglutide) and Mounjaro™ (tirzepatide), a major breakthrough for the treatment of obesity
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Effects of tirzepatide, a dual GIP and GLP-1 receptor agonist, on blood pressure, cardiac function, and sympathetic nervous system in stroke-prone spontaneously hypertensive rats
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GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard. A peptide that was discovered in Gila monster saliva, called exendin-4, was found to mimic the action
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