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glp 1 side effects skin sensitivity In four recent placebo-controlled clinical trials, dysesthesia, an unpleasant sensation that's perceived on or under the skin, was reported as a side effect of the GLP-1 agonist semaglutide in 5-23% of recipients

Marsoni M251S
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4.8 ★★★★★
Based on 107 reviews
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Verified Purchase
Daryl Johnston
Massapequa, US
★★★★★ 5
Comfortable and secure
Size: Small, Color: Black Grey
Nice quality non fly men’s underwear. Pouch holds your gear firmly. Ordered small (30” waist) but ended up ordering same item in medium for more comfort. Also went with the cotton version.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 7, 2025
M
Verified Purchase
Morstead
Birmingham, US
★★★★★ 5
Comfortable & well-fitting, but some differences in stiffness between batches
Size: Medium, Color: Black/Deep Blue/Deep Grey/Heather Grey
I've basically been exclusively buying these since I've discovered them. Super-comfortable and maintain their shape for a long time, but I've noticed from buying it multiple times that sometimes the pouch area has stiffer texture and more support than other times (when it's loose & stretchy like the rest of it). I wish I could specify receiving the more-supported ones because they tend to produce less....how to say, knocking the boys around.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 22, 2026
E
Verified Purchase
EclecticJay
Grantham, US
★★★★★ 5
Comfort and softness
Size: 3X-Large, Color: Black/Navy/Dark Grey/Red
True to size; they are comfortable, good quality, and really soft.
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Reviewed in the United States on January 3, 2026
J
Verified Purchase
James
Waukegan, US
★★★★★ 5
Look great, feel great
Size: Large, Color: Black
These feel great and fit well. With most briefs I tend to the trouble either keeping the front in or not having the back cover everything but these do both things and are very soft. They also look great, even on body types not in the promo picture. They are a great set of briefs and have held up so far and I got mine a little around a year ago and wear them often.
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Reviewed in the United States on September 26, 2025
G
Verified Purchase
garlic brad
Cuba, US
★★★★★ 4
Comfortable, but run big
Size: Small, Color: Red/Orange/Yellow/Blue
I'm a small guy and I purchased size small. The underwear are not bad. Great if you're a bigger guy or if you have a really big butt. If you're on the smaller side or skinnier though they'll fit a little loose. My butt is pretty big, but it doesn't fill out the back completely. Very comfortable though and the waist fits fine. Just a big backside. They don't ride up and so far they're durable. No fading in color and the material holds strong after many wears and washes.
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Reviewed in the United States on February 24, 2026

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