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Does Semaglutide make you tired? Hollywood Body Wraps Does Ozempic Cause Hair Loss? Here's the Truth YouTube Semaglutide and tirzepatide are both GLP 1 medications but they're not the same. Semaglutide works on one hormone (GLP 1) to reduce appetite and slow digestion. Tirzepatide works on two hormones ( Does Semaglutide Cause Muscle Loss? Preserve Muscle During Weight Loss GLP 1 medication changes may support long term weight management UT Southwestern Medical Center The FDA says it's standing by its earlier decision that the shortage of tirzepatide the active ingredient in Eli Lilly's diabetes and weight loss drugs Mounjaro and Zepbound is over.