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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial
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In a phase III trial, orforglipron yielded better HbA1c reduction compared with oral semaglutide at 52 weeks. Gastrointestinal side effects were more common with orforglipron, leading to more treatment discontinuations. Read more
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A clinical trial for diabetes that pit orforglipron, a diabetes and weight-loss pill developed by Eli Lilly, against oral semaglutide, made by Novo Nordisk, suggests the former pill may have the edge
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Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
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Orforglipron Demonstrates Superior Blood Sugar Control Compared With Oral Semaglutide
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Oral Semaglutide 25 mg and Orforglipron for Obesity: New NEJM Insights
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Orforglipron FDA Approval: Why the First Small-Molecule GLP-1 Pill Matters
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