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Tirzepatide for the Maintenance of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN - Horn - 2025 - Obesity
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Causes and consequences of discontinuation of GLP1RAs or tirzepatide
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Phentermine may help certain patients lose more weight after discontinuing GLP-1s
25.16
Many adults stop GLP-1 therapy within a year with low restart rates, analysis finds
22.63
Potential Maintenance Off-Ramp Showing Promise in early trials: Following weight loss on tirzepatide, Fractyl Health showed additional 2% weight loss 3 months after Revita procedure and discontinuation of tirzepatide vs 10% regain
27.56
Surgery works. GLP-1s work. The data on regain is brutal. Two-thirds of GLP-1 weight loss comes back within a year of stopping. 60%+ of bariatric patients regain meaningful weight. Most people stop
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Most Patients Discontinue GLP-1 Drugs Within a Year, Higher Dropout for Weight Loss Users
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