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fda warning on semaglutide The FDA sent a warning letter to the maker of Ozempic and Wegovy over unreported potential GLP-1 side effects. Here's what to know

Marsoni M251S
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Trending Topics & Drug Approvals: June 2025 Prime Therapeutics Portal CONS: Gastrointestinal side effects: Nausea, vomiting, diarrhea, and constipation affect approximately 50 60% of patients, especially during initial treatment. Muscle loss: Up to 39% of weight lost may come from lean GLP1 Plans Semaglutide & Tirzepatide Weight Loss The weight loss independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP 1 receptors: Cell Metabolism How to Restart Semaglutide Invigor Medical Development of a novel semaglutide loaded dry powder inhaler: application of freeze drying and Pharmacokinetic evaluation in rats Journal of Pharmaceutical Investigation Springer Nature Link
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4.3 ★★★★★
Based on 330 reviews
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Verified Purchase
Helena
Dallas, US
★★★★★ 5
These are definitely indestructible
Size: Medium
Both of my dogs can destroy a ball in a matter of minutes if I let them play with them (supervised) as is. Well not with these balls. They are the ONLY ones I have found that are 100% indestructible. Please only let your dogs play with these as a toy when supervised though. They go really far when throwing them, so both dogs get a good amount of running and exercise with these. I also bought these because they have the hole in the middle of the ball which is very important in the event that a dog gets one stuck at the back of their throat. This allows them to breath unlike those without this hold. It's an unlikely event, but as dog owners, we all need to be aware of this and educate ourselves on what to do if this SHOULD happen. This isn't a scare tactic, nor a reflection of this particular brand, it can happen with any type of ball. My two dogs are about 45ish lbs and the size is perfect for them, I don't want anything smaller than this. They love them. There is no annoying squeak. Really easy to wash after use. Some balls take forever to get the slimy saliva off, but these don't.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 25, 2025
A
Verified Purchase
Ale quintero
Omaha, US
★★★★★ 5
He loves this ball
Size: Medium, Size: Medium
My dog loves this ball. It’s the perfect size, he enjoys playing fetch and this ball has been his fav one. Thank you guys for making my lil one happy
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 2, 2026
A
Verified Purchase
Amazon Customer
Cuba, US
★★★★★ 5
Quiet squeaker!
My puppy loves them and I love that the squeaker isn't obnoxiously loud like her other toys.
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Reviewed in the United States on October 19, 2025
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Verified Purchase
Victoria
Whiting, US
★★★★★ 3
sufficient for my dog..
Not very durable.. Dog has chewed one in half pretty quickly and found some smaller bits around the house. This could pose a safety risk to dogs that try to also swallow these bits. If your dog is like mine and would rather play with them instead, they are cheap enough to replace them.
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Reviewed in the United States on December 18, 2025
A
Verified Purchase
Alma
Omaha, US
★★★★★ 5
Stands up to my aggressive chewer.
The squeaker stopped working almost immediately, but my dog didn't care too much. He still keeps chewing on these balls, and so far, they have stood up to his tough jaws.
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Reviewed in the United States on February 2, 2024

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