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A trial emulation in Nature Medicine shows that treatment with semaglutide and tirzepatide showed similar levels of benefit on cardiovascular outcomes in people at elevated cardiovascular risk with obesity and diabetes. Link
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Tirzepatide led to greater real-world weight loss than semaglutide for adults with obesity
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Tirzepatide cuts diabetes risk by 94% in SURMOUNT-1 trial
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Presented at #ECO2025: In the SURMOUNT-5 phase 3b trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference. Full trial results:
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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity
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Perspectives on weight control in diabetes – Tirzepatide
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Full article: Tirzepatide, a novel, dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist for the ongoing diabesity epidemic: the dawn of a new era?
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